The Addicks have not won at home since August and could scarcely have tougher opponents as they seek a second success. Boro have won their last three league games on the road. Capital One Cup victories at Preston and Sunderland boost that sequence to five.
Chris Powell will have to decide what formation to use and may opt for a more attacking 4-4-2 shape. Cedric Evina misses out through injury, so Powell will have to shuffle his pack and play a makeshift full-back.
Much will depend on the service to the front men and they will need to make the most of their chances.